{"product_id":"fish-min-minocycline","title":"Fish SMZ \/ TMP - Sulfamethoxazole \/ Trimethoprim","description":"\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cem\u003eSulfamethoxazole \/ Trimethoprim — a synergistic two-drug combination antibiotic delivering broad-spectrum coverage against resistant gram-positive and gram-negative bacterial infections in ornamental fish.\u003c\/em\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cmeta charset=\"utf-8\"\u003e \u003cspan style=\"color: rgb(0, 0, 0); background-color: rgb(255, 255, 0);\"\u003e\u003cstrong\u003eWhy SMZ-TMP works better than a single antibiotic: Unlike every other antibiotic in our lineup, SMZ-TMP contains two active ingredients that attack bacteria at two different points in their metabolic pathway simultaneously. Sulfamethoxazole blocks folate synthesis, and Trimethoprim blocks the next step in the same pathway — making it extremely difficult for bacteria to develop resistance. This synergistic dual-drug formula produces a bactericidal effect far greater than either drug alone and is particularly effective against infections that have proven resistant to single-agent antibiotics. Also commonly known as Bactrim.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(204, 204, 204);\"\u003e\u003cstrong\u003eHow the Two Ingredients Work Together\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"background-color: rgb(204, 204, 204);\"\u003e\u003cstrong\u003eSulfamethoxazole 800mg - Inhibits dihydropteroate synthase — the first enzyme in bacterial folate synthesis. Without folate, bacteria cannot produce the DNA building blocks needed to reproduce.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"background-color: rgb(204, 204, 204);\"\u003e\u003cstrong\u003eTrimethoprim 160mg - Inhibits dihydrofolate reductase — the second enzyme in the same pathway. Blocking both steps simultaneously creates a powerful one-two punch that is bactericidal at much lower concentrations.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"text-decoration: underline;\"\u003eAbout This Product\u003cmeta charset=\"utf-8\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSulfamethoxazole\/Trimethoprim (SMZ-TMP) is a synthetic combination antibiotic that pairs two drugs from different antibiotic classes into one highly effective tablet. Sulfamethoxazole is a sulfonamide antibiotic and Trimethoprim is a diaminopyrimidine — each targets a separate enzyme in the bacterial folate synthesis pathway, creating a sequential double-block that is far more bactericidal than either drug used alone.\u003c\/p\u003e\n\u003cp\u003eEach tablet contains USP-grade Sulfamethoxazole 800mg and Trimethoprim 160mg in a 100-tablet count. The standard 5:1 ratio of sulfa to trimethoprim is the clinically proven optimal synergistic dose. This makes SMZ-TMP an excellent choice for treating a wide variety of gram-positive and gram-negative infections — particularly when single-agent antibiotics have not produced results — and it is among the most versatile antibiotics in ornamental fishkeeping.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAlso commonly searched as: fish sulfa forte equivalent, SMZ TMP fish antibiotic, bactrim for fish, sulfamethoxazole trimethoprim fish, sulfamethoxazole fish, aqua SMZ equivalent, fish sulfa trim, co-trimoxazole fish antibiotic.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"text-decoration: underline;\"\u003eCommonly Treats\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFin rot \u0026amp; tail rot\u003c\/li\u003e\n\u003cli\u003eDropsy\u003c\/li\u003e\n\u003cli\u003eColumnaris (mouth rot)\u003c\/li\u003e\n\u003cli\u003eEye infections (popeye)\u003c\/li\u003e\n\u003cli\u003eBacterial hemorrhagic septicemia\u003c\/li\u003e\n\u003cli\u003eGill disease\u003c\/li\u003e\n\u003cli\u003eOpen wounds \u0026amp; body ulcers\u003c\/li\u003e\n\u003cli\u003eInfections resistant to single-agent antibiotics\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"text-decoration: underline;\"\u003eDirections for Use\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eDetermine your dose: Use one 800mg\/160mg tablet per 40 gallons of aquarium water.\u003c\/li\u003e\n\u003cli\u003eDissolve the tablet in a small amount of aquarium water before adding to the tank. Stir until fully dissolved.\u003c\/li\u003e\n\u003cli\u003eAdd directly to your aquarium, pond, or hospital\/quarantine tank.\u003c\/li\u003e\n\u003cli\u003eRepeat every 24 hours for 5–10 days. Do not exceed 10 days of continuous treatment.\u003c\/li\u003e\n\u003cli\u003ePerform a 25% water change each day before re-dosing to maintain water quality and reduce antibiotic buildup.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"text-decoration: underline;\"\u003eProduct Specifications\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"specs-table\" style=\"width: 100%; height: 293.907px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 46.3944%; height: 39.1875px;\"\u003eActive Ingredient\u003c\/td\u003e\n\u003ctd style=\"width: 53.2446%; height: 39.1875px;\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e \u003cspan\u003eSulfamethoxazole 800mg USP + Trimethoprim 160mg USP\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 46.3944%; height: 19.5938px;\"\u003eCommon Name\u003c\/td\u003e\n\u003ctd style=\"width: 53.2446%; height: 19.5938px;\"\u003e\u003cspan\u003eSMZ-TMP · Co-trimoxazole\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 46.3944%; height: 19.5938px;\"\u003eAvailable Counts\u003c\/td\u003e\n\u003ctd style=\"width: 53.2446%; height: 19.5938px;\"\u003e100 Tablets\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 46.3944%; height: 39.1875px;\"\u003eForm\u003c\/td\u003e\n\u003ctd style=\"width: 53.2446%; height: 39.1875px;\"\u003eTablet (dissolve before use)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 46.3944%; height: 39.1875px;\"\u003eAntibiotic Class\u003c\/td\u003e\n\u003ctd style=\"width: 53.2446%; height: 39.1875px;\"\u003eSulfonamide + Diaminopyrimidine (Synergistic Combination)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 46.3944%; height: 39.1875px;\"\u003eSpectrum\u003c\/td\u003e\n\u003ctd style=\"width: 53.2446%; height: 39.1875px;\"\u003eBroad-spectrum (gram-positive \u0026amp;amp; gram-negative)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 46.3944%; height: 19.5938px;\"\u003eTank Compatibility\u003c\/td\u003e\n\u003ctd style=\"width: 53.2446%; height: 19.5938px;\"\u003eFreshwater \u0026amp; saltwater ornamental fish\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 46.3944%; height: 19.5938px;\"\u003ePrescription Required\u003c\/td\u003e\n\u003ctd style=\"width: 53.2446%; height: 19.5938px;\"\u003eNo\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 46.3944%; height: 19.5938px;\"\u003eGrade\u003c\/td\u003e\n\u003ctd style=\"width: 53.2446%; height: 19.5938px;\"\u003eUSP Pharmaceutical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 46.3944%; height: 19.5938px;\"\u003eExpiration\u003c\/td\u003e\n\u003ctd style=\"width: 53.2446%; height: 19.5938px;\"\u003eTypically 1–3 years from manufacture date\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"warning-title\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"warning-title\"\u003e\u003cstrong\u003e\u003cspan style=\"text-decoration: underline;\"\u003eImportant Warnings \u0026amp; Cautions\u003c\/span\u003e\u003c\/strong\u003e\u003c\/div\u003e\n\u003cul class=\"warning-list\"\u003e\n\u003cli\u003eFor ornamental fish use only. Not intended for use in fish raised for human consumption.\u003c\/li\u003e\n\u003cli\u003eNot for human consumption. Do not ingest. This product is sold for aquarium fish treatment only.\u003c\/li\u003e\n\u003cli\u003eKeep out of reach of children. Store in a cool, dry place away from children and pets.\u003c\/li\u003e\n\u003cli\u003eDo not exceed 10 days of continuous treatment. Overuse may contribute to antibiotic resistance in your aquarium ecosystem.\u003c\/li\u003e\n\u003cli\u003eRemove activated carbon from your filter before treatment — carbon will absorb the medication and render treatment ineffective.\u003c\/li\u003e\n\u003cli\u003eAvoid direct sunlight exposure. Sulfonamide compounds can degrade under UV light. Keep the tank away from direct sunlight or dim lighting during the treatment period for best results.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 0);\"\u003e\u003cem\u003e\u003cstrong\u003e\u003cspan style=\"text-decoration: underline;\"\u003eLabel \u0026amp; Usage Disclaimer:\u003c\/span\u003e \u003c\/strong\u003ePlease read and follow all label directions before use. Product descriptions and usage instructions shown here are taken directly from the manufacturer’s product label and information provided by Montana Aquarium Supply. These statements do not represent the views or recommendations of Pittsboro Pet Supply or Pittsboro Feed. Made in the USA. Distributed by Montana Aquarium Supply – Billings, MT. \u003c\/em\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Aquarium","offers":[{"title":"800 mg x 160 mg \/ 100 ct","offer_id":43092390772802,"sku":"PPS-BIN 4","price":33.96,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2680\/2846\/files\/Fish_SMZ_TMP_-_Sulfamethoxazole_Trimethoprim_800mg_160mg_100_count.png?v=1773696962","url":"https:\/\/pittsboropetsupply.com\/products\/fish-min-minocycline","provider":"Pittsboro Pet Supply","version":"1.0","type":"link"}